A toy building block robot and a main control box thereof are disclosed. The main control box comprises a toy building-block robot main control housing, a toy building-block robot main control board, and a battery. The toy building-block robot main control board is installed in the toy building-block robot main control housing. The battery is connected to the toy building-block robot main control board, so as to supply power to the toy building-block robot main control board. A plurality of connection mechanisms are disposed on the toy building-block robot main control housing for engaging the toy building-block robot main control housing with other components of the toy building block robot. In the present disclosure, whether the assembly of the components in the main control box, or the engagement between the main control box and other components of the toy building block robot, can both be realized through a connection mechanism.