![Substituted 1H-pyrrolo [2, 3-b] pyridine and 1H-pyrazolo [3, 4-b] pyridine derivatives as salt inducible kinase 2 (SIK2) inhibitors](/docs/US/2018-02-13/US09890153B2/abs.jpg.600x600.jpg)
- 专利标题： Substituted 1H-pyrrolo [2, 3-b] pyridine and 1H-pyrazolo [3, 4-b] pyridine derivatives as salt inducible kinase 2 (SIK2) inhibitors
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申请号： US14958622申请日： 2015-12-03
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公开(公告)号： US09890153B2公开(公告)日： 2018-02-13
- 发明人: Hariprasad Vankayalapati , Venkatakrishnareddy Yerramreddy , Venu Babu Ganipisetty , Sureshkumar Talluri , Rajendra P Appalaneni
- 申请人： Arrien Pharmaceuticals LLC
- 申请人地址： US UT Salt Lake City
- 专利权人： ARRIEN PHARMACEUTICALS LLC
- 当前专利权人： ARRIEN PHARMACEUTICALS LLC
- 当前专利权人地址： US UT Salt Lake City
- 代理机构： Gibson & Dernier LLP
- 代理商 Timothy X. Gibson, Esq.
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; A61K31/437 ; A61K31/444 ; A61K31/4545 ; A61K31/496 ; A61K31/5377 ; A61K31/635
![Substituted 1H-pyrrolo [2, 3-b] pyridine and 1H-pyrazolo [3, 4-b] pyridine derivatives as salt inducible kinase 2 (SIK2) inhibitors](/abs-image/US/2018/02/13/US09890153B2/abs.jpg.150x150.jpg)
摘要：
Compounds according to Formulas I, IA or IB: to pharmaceutically acceptable composition, salts thereof, their synthesis and their use as SIK2 inhibitors including such compounds and methods of using said compounds in the treatment of various diseases and/or disorders such as cancer, stroke, cardiovascular, obesity and type II diabetes.
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