- 专利标题： Staphylococcus aureus SpA5 mutant, composition comprising mutant and preparation method and use thereof
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申请号： US15103173申请日： 2013-12-09
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公开(公告)号： US09890199B2公开(公告)日： 2018-02-13
- 发明人: Quanming Zou , Hao Zeng , Shaowen Fan , Lu Lu , Qiang Feng , Jinyong Zhang , Haiming Jing , Yandong Dong , Yi Wu , Changzhi Cai
- 申请人： OLYMVAX BIOPHARMACEUTICALS INC. , THIRD MILITARY MEDICAL UNIVERSITY, PLA
- 申请人地址： CN Chengdu CN Chongqing
- 专利权人： Olymvax Biopharmaceuticals Inc.,Third Military Medical University, PLA
- 当前专利权人： Olymvax Biopharmaceuticals Inc.,Third Military Medical University, PLA
- 当前专利权人地址： CN Chengdu CN Chongqing
- 代理机构： Calfee, Halter & Griswold LLP
- 国际申请： PCT/CN2013/088880 WO 20131209
- 国际公布： WO2015/085463 WO 20150618
- 主分类号： C07K14/31
- IPC分类号： C07K14/31 ; A61K39/085 ; G01N33/569 ; A61K39/40 ; C07K16/12 ; C12N15/70 ; A61K39/00
摘要：
Provided is staphylococcus protein A expressed by a mutational Staphylococcus aureus and its coding sequence, as well as a vector, host bacteria, composition or kit which contains the coding sequence of the mutational protein. Also provided is the use of the mutational protein and the composition thereof in the preparation of vaccines, therapeutic antibodies, diagnostic kits and the like, and for the prevention, treatment and detection of infections by Staphylococcus aureus. Also provided are methods for producing, fermenting and purifying the mutational protein.
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