Invention Grant
- Patent Title: N-pyrrolidinyl,N′-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
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Application No.: US14442613Application Date: 2013-11-12
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Publication No.: US09896435B2Publication Date: 2018-02-20
- Inventor: Shelley Allen , Barbara J. Brandhuber , Timothy Kercher , Gabrielle R. Kolakowski , Shannon L. Winski
- Applicant: Array BioPharma Inc.
- Applicant Address: US CO Boulder
- Assignee: Array BioPharma Inc.
- Current Assignee: Array BioPharma Inc.
- Current Assignee Address: US CO Boulder
- Agency: Viksnins Harris Padys Malen LLP
- Agent Sarah S. Mastous
- International Application: PCT/US2013/069729 WO 20131112
- International Announcement: WO2014/078323 WO 20140522
- Main IPC: C07D401/14
- IPC: C07D401/14 ; C07D403/12 ; C07D403/14

Abstract:
Compounds of Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts, or solvates or prodrugs thereof, where R1, R2, Ra, Rb, Rc, Rd, X, Ring B, and Ring C are as defined herein, and wherein Ring B and the NH—C(═X)—NH moiety are in the trans configuration, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis or pelvic pain syndrome.
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