The present disclosure provides a pixel structure, its driving method and a display device. The pixel structure comprises a plurality of repeating units consisting of subpixels. Each repeating unit comprises four subpixels in different colors, which are divided into two groups. Each group of subpixels includes a subpixel with its major-axis direction as a first direction and a subpixel with its major-axis as a second direction perpendicular to the first direction.