A vehicle body frame of a saddle-ride-type vehicle which enables a high-strength joint and a reduction in the weight of the vehicle body frame. The vehicle body frame of a saddle-ride-type vehicle includes a plurality of rear frames arranged to face each other in an opposed manner and a cross frame for connecting the plurality of rear frames to each other. A through hole is formed in the rear frames arranged to face each other in an opposed manner with the cross frame being joined to the rear frames at insertion portions thereof inserted into the through holes.