- 专利标题： Collagen matrix with locally controlled intrafibrillar and extrafibrillar mineral content and methods of producing
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申请号： US14169573申请日： 2014-01-31
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公开(公告)号： US09908929B2公开(公告)日： 2018-03-06
- 发明人: Lester Smith , Stavros Thomopoulos
- 申请人： The Washington University
- 申请人地址： US MO Saint Louis
- 专利权人： WASHINGTON UNIVERSITY
- 当前专利权人： WASHINGTON UNIVERSITY
- 当前专利权人地址： US MO Saint Louis
- 代理机构： Polsinelli PC
- 主分类号： C07K14/78
- IPC分类号： C07K14/78 ; A61K38/39 ; A61L27/12 ; A61L27/24 ; A61L27/46
摘要：
A mineralized collagen matrix with an intrafibrillar and/or extrafibrillar gradient of mineralization for insertion replacement is disclosed. The intrafibrillar mineralization of the collagen matrix is formed by the addition of fetuin to the simulated body fluid. The gradient of intrafibrillar mineralization may stiffen the collagen matrix and simulate a natural insertion for improved cell infiltration and regeneration.
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