- 专利标题： Compounds and methods for modulating apolipoprotein C-III expression for improving a diabetic profile
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申请号： US14900320申请日： 2014-06-23
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公开(公告)号： US09909124B2公开(公告)日： 2018-03-06
- 发明人: Rosanne M. Crooke , Veronica J. Alexander
- 申请人： ISIS PHARMACEUTICALS, INC.
- 申请人地址： US CA Carlsbad
- 专利权人： Ionis Pharmaceuticals, Inc.
- 当前专利权人： Ionis Pharmaceuticals, Inc.
- 当前专利权人地址： US CA Carlsbad
- 代理机构： Grant IP
- 国际申请： PCT/US2014/043723 WO 20140623
- 国际公布： WO2014/205449 WO 20141224
- 主分类号： C12N15/113
- IPC分类号： C12N15/113 ; A61K31/155 ; A61K31/713
摘要：
Provided herein are improved compounds, compositions and associated methods for reducing expression of ApoCIII mRNA and protein in a subject having, or at risk of having, diabetes. Also provided herein are compounds, compositions and associated methods improving peripheral insulin sensitivity, a lipid profile and a diabetes profile as well as reducing free fatty acids and intramyocellular triglyceride deposition.
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