Certain examples provide methods, systems and apparatus of content-driven clinical information management. An example method includes facilitating authoring of content and combination of the content into a content-based application, wherein content represents a parameterization of instructions to instruct the content-based application how to operate, the content formulated according to one or more detailed clinical models. The example method includes packaging and deploying the content-based application using a processor to one or more targets for installation. The example method includes facilitating installation of the packaged content-based application at the one or more targets. The example method includes managing the content-based application remotely from the one or more targets. In the example method, content is to be created, stored, deployed, and retrieved independently of the creation and deployment of the content-based application consuming data based on the content.