An example method for characterizing interference relationships in full duplex cable network environments is provided and includes generating a global interfered list for a plurality of cable modems in the cable network and for a plurality of frequency ranges, generating a global interfering list for the plurality of cable modems and for the plurality of frequency ranges, assigning respective downstream reception frequency ranges and upstream transmission frequency ranges for the plurality of cable modems based on the global interfered list and the global interfering list, and transmitting to the cable modems corresponding assignment information comprising the respective assigned downstream reception frequency ranges and upstream transmission frequency ranges.