The present invention relates to an interleaving and de-interleaving method, an interleaver and a de-interleaver. The interleaving method includes: receiving N×M frames of data, and sequentially storing, with each frame as a unit, the N×M frames of data in storage space indicated by N×M addresses of a first storage unit; transferring the data stored in the storage space indicated by an ((X−1)×M+Y+1)th address of the first storage unit to the storage space indicated by a (Y×N+X)th address of a second storage unit; and according to an address sequence, outputting the data stored in the space indicated by the N×M addresses of the second storage unit frame by frame. The interleaving and de-interleaving solutions of the present invention have low implementation complexity, and high capacity of correcting a burst bit error.