- 专利标题： TLR-independent small molecule adjuvants
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申请号： US15502117申请日： 2015-08-05
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公开(公告)号： US09918959B2公开(公告)日： 2018-03-20
- 发明人: Dale Boger , Bruce Beutler
- 申请人： The Scripps Research Institute , Board of Regents of the University of Texas System, Austin
- 申请人地址： US TX Austin US CA La Jolla
- 专利权人： The Board of Regents of the University of Texas System,The Scripps Research Institute
- 当前专利权人： The Board of Regents of the University of Texas System,The Scripps Research Institute
- 当前专利权人地址： US TX Austin US CA La Jolla
- 代理机构： Husch Blackwell LLP
- 国际申请： PCT/US2015/043830 WO 20150805
- 国际公布： WO2016/022700 WO 20160211
- 主分类号： C07D307/79
- IPC分类号： C07D307/79 ; C07D333/50 ; A61K31/343 ; A61K31/167 ; A61K31/381 ; A61K31/404 ; A61K31/4439 ; C07D307/85 ; A61K39/39 ; C07D209/42 ; C07D405/12 ; C07D401/12 ; C07D409/12 ; A61K31/498 ; C07D403/12 ; A61K31/506 ; C07C237/44
摘要：
A TLR-independent adjuvant compound that corresponds in structure to Formula I, below, or its pharmaceutically acceptable salt is disclosed in which X, Y, Z, n, R1, R2, R3, R4 and W are defined within. Also disclosed are a method of its preparation and use, as well as a pharmaceutical composition containing the same.
公开/授权文献
- US20170224653A1 TLR-INDEPENDENT SMALL MOLECULE ADJUVANTS 公开/授权日：2017-08-10
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