- 专利标题: Polyvinylpyrrolidone for the stabilization of a solid dispersion of the non-crystalline form of rotigotine
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申请号: US13515067申请日: 2010-12-22
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公开(公告)号: US09925150B2公开(公告)日: 2018-03-27
- 发明人: Hans-Michael Wolff , Christoph Arth , Luc Quere , Walter Müller
- 申请人: Hans-Michael Wolff , Christoph Arth , Luc Quere , Walter Müller
- 申请人地址: DE Andernach DE Monheim
- 专利权人: LTS Lohmann Therapie-Systeme AG,UCB Pharma GmbH
- 当前专利权人: LTS Lohmann Therapie-Systeme AG,UCB Pharma GmbH
- 当前专利权人地址: DE Andernach DE Monheim
- 代理机构: Harness, Dickey and Pierce, P.L.C.
- 国际申请: PCT/EP2010/070563 WO 20101222
- 国际公布: WO2011/076879 WO 20110630
- 主分类号: A61K31/381
- IPC分类号: A61K31/381 ; A61K9/70
摘要:
The present invention relates to a method for stabilizing rotigotine, the method comprising providing a solid dispersion comprising polyvinylpyrrolidone and a non-crystalline form of rotigotine, wherein the weight ratio of rotigotine to polyvinylpyrrolidone is in a range from about 9:3.5 to about 9:6. The present invention also relates to a solid dispersion comprising a dispersing agent and a dispersed phase, said dispersed phase comprising rotigotine and polyvinylpyrrolidone, wherein the weight ratio of rotigotine to polyvinylpyrrolidone is in a range from about 9:3.5 to about 9:6, a pharmaceutical composition comprising such a solid dispersion, in particular a transdermal therapeutic system, as well as a method for the preparation thereof.
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