- 专利标题： Antibody drug conjugates (ADC) that bind to CD37 proteins
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申请号： US14447209申请日： 2014-07-30
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公开(公告)号： US09925273B2公开(公告)日： 2018-03-27
- 发明人: Daniel Sousa Pereira , Faisal Hayat Malik , Josh Snyder , Leslie Renee Butterworth , Ssucheng Jeff Hsu , Peng Yang , Claudia Isabel Guevara
- 申请人： AGENSYS, INC.
- 申请人地址： US CA Santa Monica
- 专利权人： AGENSYS, INC.
- 当前专利权人： AGENSYS, INC.
- 当前专利权人地址： US CA Santa Monica
- 代理机构： Jones Day
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61K47/48 ; A61K45/06
摘要：
Antibody drug conjugates (ADC's) that bind to CD37 protein and variants thereof are described herein. CD37 exhibits a distinct and limited expression pattern in normal adult tissue(s), and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention in some embodiments provide a therapeutic composition for the treatment of cancer.
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