- 专利标题: Allosteric modulators of nicotinic acetylcholine receptors
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申请号: US15727982申请日: 2017-10-09
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公开(公告)号: US09926285B2公开(公告)日: 2018-03-27
- 发明人: Brendan M. Crowley , Brian T. Campbell , Joseph L. Duffy , Andrew John Harvey , Ian M. Bell
- 申请人: MERCK SHARP & DOHME CORP.
- 申请人地址: US NJ Rahway
- 专利权人: Merck Sharp & Dohme Corp.
- 当前专利权人: Merck Sharp & Dohme Corp.
- 当前专利权人地址: US NJ Rahway
- 代理商 Matthew A. Leff; Gloria M. Fuentes
- 主分类号: C07D285/12
- IPC分类号: C07D285/12 ; C07D231/12 ; C07D249/04 ; C07D261/08 ; C07D263/32 ; C07D271/06 ; C07D277/26 ; C07D285/08 ; A61K31/4192 ; A61K31/42 ; A61K31/421 ; A61K31/4245 ; A61K31/426 ; A61K31/433 ; A61K31/415 ; C07D271/107
摘要:
The present disclosure relates to compounds of formula I that are useful as modulators of α7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation
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