A dynamic adjustment method while driving a vehicle of at least one vehicle operating parameter is for a vehicle having an electronic control unit adapted to set the operating parameter, and a communication interface operatively connected to the electronic control unit. An application program is installed on board a portable processing device including a communication interface communicating with the vehicle communication interface. The application program accesses an electronic map of a path and divides the path in sectors. Operating parameter values are stored via the application program, each value being associated to a corresponding sector. While driving, the sector occupied by the vehicle is identified in real time. Values are transmitted sector by sector, from the portable processing device to the electronic control unit so that the electronic control unit sets, sector by sector, the vehicle operating parameter vehicle to the value associated to the occupied sector.