Invention Grant
- Patent Title: N-azaspirocycloalkane substituted N-heteroaryl compounds and compositions for inhibiting the activity of SHP2
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Application No.: US15110511Application Date: 2015-01-16
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Publication No.: US09938295B2Publication Date: 2018-04-10
- Inventor: Christine Hiu-Tung Chen , Zhuoliang Chen , Michael Dore , Jorge Garcia Fortanet , Rajesh Karki , Mitsunori Kato , Matthew J. LaMarche , Lawrence Blas Perez , Troy Douglas Smith , Sarah Williams , John William Giraldes , Martin Sendzik , Bakary-Barry Toure
- Applicant: Christine Hiu-Tung Chen , Zhuoliang Chen , Michael Dore , Jorge Garcia Fortanet , Rajesh Karki , Mitsunori Kato , Matthew J. LaMarche , Lawrence Blas Perez , Troy Douglas Smith , Sarah Williams , John William Giraldes , Martin Sendzik , Bakary-Barry Toure
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agency: Genomics Institute of the Novartis Research Foundation
- Agent Daniel E. Raymond
- International Application: PCT/IB2015/050345 WO 20150116
- International Announcement: WO2015/107495 WO 20150723
- Main IPC: C07D498/10
- IPC: C07D498/10 ; C07D241/18 ; C07D241/20 ; C07D401/04 ; C07D401/14 ; C07D403/04 ; C07D471/10 ; C07D491/107 ; C07D495/10
Abstract:
The present invention relates to compounds of formula I: in which p, q, Y1, Y2, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5a, R5b, R7 and R8 are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.
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