Invention Grant
- Patent Title: Glycosidase inhibitors and uses thereof
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Application No.: US14655222Application Date: 2013-12-20
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Publication No.: US09938299B2Publication Date: 2018-04-10
- Inventor: Harold G. Selnick , Kun Liu , Ernest J. McEachern , Ramesh Kaul , Zhongyong Wei , Yaode Wang , Jiang Chang
- Applicant: MERCK SHARP & DOHME CORP. , ALECTOS THERAPEUTICS, INC.
- Applicant Address: CA Burnaby, British Colombia US NJ Rahway
- Assignee: ALECTOS THERAPEUTICS, INC.,MERCK SHARP & DOHME CORP.
- Current Assignee: ALECTOS THERAPEUTICS, INC.,MERCK SHARP & DOHME CORP.
- Current Assignee Address: CA Burnaby, British Colombia US NJ Rahway
- Agent J. Eric Thies; John C. Todaro
- Priority: WOPCT/CN2012/087286 20121224
- International Application: PCT/US2013/076768 WO 20131220
- International Announcement: WO2014/105662 WO 20140703
- Main IPC: C07D513/04
- IPC: C07D513/04 ; B65D71/14 ; B65D71/16 ; B65D5/00 ; B65D5/20
Abstract:
The invention provides compounds with enhanced permeability for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
Public/Granted literature
- US20160194337A1 GLYCOSIDASE INHIBITORS AND USES THEREOF Public/Granted day:2016-07-07
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