Invention Grant
- Patent Title: Amatoxin derivatives and conjugates thereof as inhibitors of RNA polymerase
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Application No.: US15524197Application Date: 2015-11-05
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Publication No.: US09938323B2Publication Date: 2018-04-10
- Inventor: Jan Grunewald , Yunho Jin , Weijia Ou , Tetsuo Uno
- Applicant: NOVARTIS AG
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agency: Genomics Institute of the Novartis Research Foundation
- Agent Daniel E. Raymond
- International Application: PCT/IB2015/058537 WO 20151105
- International Announcement: WO2016/071856 WO 20160512
- Main IPC: A61K38/00
- IPC: A61K38/00 ; C07K7/64 ; C07K16/22 ; C07K16/30
Abstract:
The invention disclosed herein relates to cytotoxic cyclic peptides of Formula (I), methods of inhibiting RNA polymerase with such cyclic peptides, immunoconjugates comprising such cyclic peptides (i.e Antibody Drug Conjugates), pharmaceutical compositions comprising such cyclic peptides immunoconjugates, compositions comprising such cyclic peptides immunoconjugates with a therapeutic co-agent and methods of treatment using such cyclic peptides immunoconjugates:
Public/Granted literature
- US20170355731A1 AMATOXIN DERIVATIVES AND CONJUGATES THEREOF AS INHIBITORS OF RNA POLYMERASE Public/Granted day:2017-12-14
Information query
IPC分类:
