A semiconductor device includes an operational transconductance amplifier (OTA) with a matched pair of transistors including a first transistor and a second transistor, and configuration units that include a first set of switches, a second set of switches, and an input transistor. Gain adjustment circuitry is coupled to adjust gain of the OTA. Measurement circuitry is coupled to measure offset in the OTA. Control logic is configured to operate the first and second sets of switches to couple input transistors of a first group of the configuration units to the first transistor of the matched pair of transistors, and to couple input transistors of a remaining group of the configuration units to the second transistor of the matched pair of transistors. Settings of the first and second sets of switches are selected to minimize the offset.