- Patent Title: Anti-DLL4/VEGF dual variable domain immunoglobulin and uses thereof
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Application No.: US14845511Application Date: 2015-09-04
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Publication No.: US09944720B2Publication Date: 2018-04-17
- Inventor: Jijie Gu , Dominic J. Ambrosi , Susan E. Lappe , Yingchun Li , Jonathan A. Hickson , Deanna L. Haasch , Supriya Gupta , Ravi Chari , Camellia Zamiri , Louie Naumovski , Xianhua Cao
- Applicant: AbbVie Inc.
- Applicant Address: US IL North Chicago
- Assignee: AbbVie Inc.
- Current Assignee: AbbVie Inc.
- Current Assignee Address: US IL North Chicago
- Agent Glen Gesicki
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C12P21/06 ; C12N1/12 ; C12N1/20 ; C12N15/00 ; C12N5/00 ; C07K16/46 ; A61K45/06 ; C07K16/22 ; A61K39/395 ; A61K31/513 ; A61K31/7068 ; A61K31/337 ; A61K31/4745 ; A61K31/495 ; A61K31/525 ; C07K16/28 ; C07K16/00 ; A61K39/00
Abstract:
Disclosed herein are multivalent and multispecific binding proteins, methods of making the binding proteins, and their uses in the diagnosis, monitoring, inhibition, prevention and/or treatment of cancers, tumors, and/or other angiogenesis-dependent diseases diseases characterized by aberrant DLL4 and/or VEGF expression or activity.
Public/Granted literature
- US20160122439A1 ANTI-DLL4/VEGF DUAL VARIABLE DOMAIN IMMUNOGLOBULIN AND USES THEREOF Public/Granted day:2016-05-05
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