Invention Grant
- Patent Title: Compositions and methods for detecting and quantifying host cells protein in cell lines and recombinant polypeptide products
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Application No.: US15065615Application Date: 2016-03-09
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Publication No.: US09945858B2Publication Date: 2018-04-17
- Inventor: Feny Gunawan , Yi-Chun Hsiao , Denise C. Krawitz , Margaret S. Lin , Martin Vanderlaan , Rajesh Vij , Inn H. Yuk , Judith Zhu-Shimoni
- Applicant: Genentech, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: McNeill Baur PLLC
- Main IPC: G01N33/577
- IPC: G01N33/577 ; G01N33/573 ; C07K16/40
Abstract:
Monoclonal and polyclonal antibodies that bind hamster phospholipase B-like 2 are provided. Also provided are methods for detecting and quantifying hamster phospholipase B-like 2, for example, in recombinant polypeptide preparations, as well as kits for carrying out such methods. Methods of screening or selecting host cell lines or recombinant polypeptide-expressing cell lines that express low levels of hamster phospholipase B-like 2 are also provided.
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