The present disclosure provides a voltage drop compensation method, a voltage drop compensation device and a display device. The voltage drop compensation method includes steps of determining a voltage drop for a power signal corresponding to each subpixel set; determining a first equivalent brightness reduction value corresponding to the voltage drop; calculating an initial brightness value for each subpixel in the subpixel set; calculating a sum of the first equivalent brightness reduction value corresponding to the subpixel set and the initial brightness value as a target brightness value for each subpixel in the subpixel set; and generating a driving signal for each subpixel in accordance with the target brightness value for each subpixel in the subpixel set, and outputting the driving signal.