Invention Grant
- Patent Title: Tricyclic indole Mcl-1 inhibitors and uses thereof
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Application No.: US14885181Application Date: 2015-10-16
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Publication No.: US09949965B2Publication Date: 2018-04-24
- Inventor: Taekyu Lee , Jason P. Burke , Edward T. Olejniczak , Johannes Belmar , Zhiguo Bian , Stephen W. Fesik
- Applicant: Vanderbilt University
- Applicant Address: US TN Nashville
- Assignee: Vanderbilt University
- Current Assignee: Vanderbilt University
- Current Assignee Address: US TN Nashville
- Agency: Michael Best & Friedrich LLP
- Main IPC: A61K31/554
- IPC: A61K31/554 ; A61K31/542 ; A61K31/4745 ; C07D513/06 ; C07D471/08 ; C07D498/06 ; A61K31/5383 ; A61K45/06
Abstract:
The present invention provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present invention also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of Mcl-1 protein.
Public/Granted literature
- US20160106731A1 TRICYCLIC INDOLE MCL-1 INHIBITORS AND USES THEREOF Public/Granted day:2016-04-21
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