Technology related to an apparatus and method for supporting a diagnosis of a lesion is provided. The apparatus includes a standard image determiner to determine, as a standard image, an image where a region of interest (ROI) is detected among a plurality of images received from an image collecting device, a candidate image extractor to extract one or more candidate images with respect to the determined standard image, a comparison image selector to select one or more comparison images for supporting a diagnosis of the ROI from the one or more candidate images, and an interface to provide a user with an output result of the standard image and the one or more selected comparison images.