The subject matter described herein includes systems, methods, and computer readable media for selective Diameter topology hiding. The system includes a Diameter agent including a network interface configured to receive, from a first Diameter node in a first service provider network, a first Diameter signaling message including Diameter topology information and a Diameter topology hiding module (THM). In some aspects, the THM is configured to determine a trust relationship between the first service provider network and a second service provider network to which the first Diameter signaling message is addressed, in response to determining that the trust relationship requires at least some level of topology hiding, determine a topology hiding type based on the first Diameter signaling message, and modify, based on the topology hiding type, the Diameter topology information included in the first Diameter signaling message to hide at least some of the Diameter topology information.