Invention Grant
- Patent Title: N-(arylalkyl)-N′-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
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Application No.: US14442576Application Date: 2013-11-12
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Publication No.: US09969694B2Publication Date: 2018-05-15
- Inventor: James F. Blake , Barbara J. Brandhuber , Julia Haas , Brad Newhouse , Allen A. Thomas , Shannon L. Winski
- Applicant: Array BioPharma Inc.
- Applicant Address: US CO Boulder
- Assignee: Array BioPharma Inc.
- Current Assignee: Array BioPharma Inc.
- Current Assignee Address: US CO Boulder
- Agency: Viksnins Harris Padys Malen LLP
- Agent Sarah S. Mastous
- International Application: PCT/US2013/069750 WO 20131112
- International Announcement: WO2014/078331 WO 20140522
- Main IPC: C07D231/38
- IPC: C07D231/38 ; C07D231/52 ; C07D403/12 ; C07D401/14 ; C07D231/40 ; C07D231/54 ; C07D401/04 ; C07D401/12 ; C07D403/04 ; C07D413/12 ; C07D495/04 ; C07D405/12 ; C07D405/14 ; C07D453/02

Abstract:
Compounds of Formula I or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C, X, Ra, Rb, Rc, Rd and n are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis or pelvic pain syndrome.
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