- 专利标题： Aryl linked imidazole and triazole derivatives and methods of use thereof for improving the pharmacokinetics of a drug
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申请号： US15036274申请日： 2014-11-07
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公开(公告)号： US09975888B2公开(公告)日： 2018-05-22
- 发明人: Craig A. Coburn , Milana M. Maletic , Yunfu Luo , Zhiqi Qi , Chun Sing Li , Tingting Yu
- 申请人： MERCK SHARP & DOHME CORP.
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 代理商 Jeffrey P. Bergman; Catherine D. Fitch
- 优先权： WOPCT/CN2013/086919 20131112
- 国际申请： PCT/US2014/064461 WO 20141107
- 国际公布： WO2015/073308 WO 20150521
- 主分类号： C07D417/14
- IPC分类号： C07D417/14 ; C07D417/12 ; C07D487/04 ; C07D401/12 ; C07D405/14 ; C07D403/10 ; C07D401/14 ; A61K45/06 ; A61K31/427 ; A61K31/4439 ; A61K31/454 ; A61K31/4545 ; A61K31/4725 ; A61K31/496 ; A61K31/4985 ; C07D409/14 ; C07D471/04 ; A61K31/4178 ; A61K31/5377
摘要：
The present invention relates to aryl linked imidazole and triazole derivatives, compositions comprising said compounds, alone or in combination with other drugs, and methods of using the compounds for improving the pharmacokinetics of a drug. The compounds of the invention are useful in human and veterinary medicine for inhibiting CYP3A4 and for improving the pharmacokinetics of a therapeutic compound that is metabolized by CYP3A4.