- 专利标题： Bicyclic AZA compounds as muscarinic M1 receptor antagonists
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申请号： US15595107申请日： 2017-05-15
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公开(公告)号： US09975890B2公开(公告)日： 2018-05-22
- 发明人: Giles Albert Brown , Julie Elaine Cansfield , Miles Stuart Congreve , Mark Pickworth , Benjamin Gerald Tehan
- 申请人： Heptares Therapeutics Limited
- 申请人地址： GB Welwyn Garden City
- 专利权人： Heptares Therapeutics Limited
- 当前专利权人： Heptares Therapeutics Limited
- 当前专利权人地址： GB Welwyn Garden City
- 代理机构： McCarter & English, LLP
- 代理商 Steven G. Davis; Mei Bai
- 主分类号： C07D401/04
- IPC分类号： C07D401/04 ; C07D451/04 ; C07D401/08
摘要：
This invention relates to compounds (Formula (1)) that are agonists of the muscarinic M1 receptor and which are useful in the treatment of muscarinic M1 receptor mediated diseases. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds. Compounds provided are of formula where R1-R5, X1, X2 and p are as defined herein.
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