The present document discloses a method and apparatus for compensating for a lost frame in a transform domain, comprising: calculating frequency-domain coefficients of a current lost frame using frequency-domain coefficients of one or more frames prior to the current lost frame, and performing frequency-time transform to obtain an initially compensated signal; and performing waveform adjustment, to obtain a compensated signal. Alternatively, extrapolation is performed for all or part of frequency points of the current lost frame using phases and amplitudes of corresponding frequency points of a plurality of previous frames to obtain phases and amplitudes of the corresponding frequency points of the current lost frame, to obtain frequency-domain coefficients of the corresponding frequency points, and frequency-time transform is performed to obtain a compensated signal. The above methods can be selected through a judgment algorithm to compensate for the current lost frame, thereby achieving a better compensation effect.