Systems and methods are provided for optimizing power allocation in distributed antenna systems and other signal distribution systems using variable and static gains. A power optimization sub-system can receive downlink signals from one or more base stations. The power optimization sub-system can group the downlink signals into a first set of downlink signals for which a static gain is to be applied and a second set of downlink signals for which a variable gain is to be applied. The power optimization sub-system can determine a gain for at least some of the signals to which a variable gain is to be applied. The determined gain can be sufficient to achieve a target metric. The power optimization sub-system can apply the static gain to the first set of signals and apply the determined gain to the second set of signals.