- 专利标题： 1,5-Disubstituted 1,2,3-triazoles are inhibitors of Rac/Cdc42 GTPases
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申请号： US15499532申请日： 2017-04-27
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公开(公告)号： US09981980B2公开(公告)日： 2018-05-29
- 发明人: Cornelis P. Vlaar , Suranganie Dharmawardhane Flanagan , Eliud Hernandez-O'Farrill , Linette Castillo-Pichardo
- 申请人： UNIVERSITY OF PUERTO RICO
- 申请人地址： US PR San Juan
- 专利权人： University of Puerto Rico
- 当前专利权人： University of Puerto Rico
- 当前专利权人地址： US PR San Juan
- 代理机构： Barnes & Thornburg LLP
- 代理商 Alice O. Martin
- 主分类号： C07D491/048
- IPC分类号： C07D491/048 ; C07D403/04 ; C07D409/14 ; C07D401/14
摘要：
Compounds are disclosed that inhibit RhoGTPases that are useful for inhibiting hyperprofilerative and neoplastic diseases. Specifically, the compounds inhibit the GTPases Rac and Cdc42 that are overactive or overexpressed in signaling pathways in cancer and metastasis. Methods for treatment of cancer and hyperproliferative diseases are disclosed.
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