A tube seal assembly is provided to connect a tube and an adapter in order to circulate a fluid. The tube seal assembly can include various components such as a locking flange, a tube retainer, a seal guard, and an elastomeric seal. Bolts are used to secure the components of tube seal assembly together through the use of a load and to secure the tube seal assembly to the second tube. Teeth on the tube retainer are angled to dig into the first tube to prevent the tube from separating from the adapter during a blowout. The tube seal assembly can be configured to connect to any existing tube in order to be more serviceable in the field.