An image sensing device includes a single-color image sensor and a multi-color image sensor having resolutions different from each other; image data receiving circuitry configured to receive first image data from the single-color image sensor and second image data from the multi-color image sensor; first preprocessor circuitry configured to generate first aligned image data and second aligned image data based on the first image data and the second image data, respectively, by correcting an optical path difference between a pixel stream of the first image data and a pixel stream of the second image; and second preprocessor circuitry configured to generate third image data by merging the first aligned image data and the second aligned image data.