- 专利标题: Engineering of strong, pliable tissues
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申请号: US10782750申请日: 2004-02-19
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公开(公告)号: USRE42479E1公开(公告)日: 2011-06-21
- 发明人: Joseph P. Vacanti , Christopher K. Breuer , Berverly E. Chaignaud , Toshiraru Shin'oka
- 申请人: Joseph P. Vacanti , Christopher K. Breuer , Berverly E. Chaignaud , Toshiraru Shin'oka
- 申请人地址: US MA Boston
- 专利权人: Children's Medical Center Corporation
- 当前专利权人: Children's Medical Center Corporation
- 当前专利权人地址: US MA Boston
- 代理机构: Pabst Patent Group LLP
- 主分类号: A61F2/24
- IPC分类号: A61F2/24
摘要:
It has been discovered that improved yields of engineered tissue following implantation, and engineered tissue having enhanced mechanical strength and flexibility or pliability, can be obtained by implantation, preferably subcutaneously, of a fibrous polymeric matrix for a period of time sufficient to obtain ingrowth of fibrous tissue and/or blood vessels, which is the removed for subsequent implantation at the site where the implant is desired. The matrix is optionally seeded prior to the first implantation, after ingrowth of the fibrous tissue, or at the time of reimplantation. The time required for fibrous ingrowth typically ranges from days to weeks. The method is particularly useful in making valves and tubular structures, especially heart valves and blood vessels.
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