再颁专利
USRE45314E1 N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors
有权
N-羟基磺酰胺衍生物作为新的生理有用的硝酰基供体
- 专利标题： N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors
- 专利标题（中）： N-羟基磺酰胺衍生物作为新的生理有用的硝酰基供体
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申请号： US14045404申请日： 2013-10-03
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公开(公告)号： USRE45314E1公开(公告)日： 2014-12-30
- 发明人: John P. Toscano , Frederick Arthur Brookfield , Andrew D. Cohen , Stephen Martin Courtney , Lisa Marie Frost , Vincent Jacob Kalish
- 申请人： Cardioxyl Pharmaceuticals, Inc. , The Johns Hopkins University
- 申请人地址： US MD Baltimore US NC Chapel Hill
- 专利权人： The Johns Hopkins University,Cardioxyl Pharmaceuticals, Inc.
- 当前专利权人： The Johns Hopkins University,Cardioxyl Pharmaceuticals, Inc.
- 当前专利权人地址： US MD Baltimore US NC Chapel Hill
- 代理机构： Dechert LLP
- 主分类号： C07C311/48
- IPC分类号： C07C311/48 ; C07D333/36 ; C07D215/36 ; A61K31/18
摘要：
The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.
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