The invention involves a system for the deployment of biologically active materials in a bodily passage, particularly in vascular wall tissue, in the form of an elongated multi-lumen catheter having a plurality of serially situated functional zones. One embodiment includes an externally accessed dispersion zone adapted to address a vascular segment and having a dispersion chamber subtending a major arc of the vascular circumference provided with a pattern of openings (40) for deploying biologically active materials in the vascular segment and supplied through an externally connected lumen.