Invention Application
WO1996023806A1 RAPID SYNTHESIS OF RADIOLABELED PYRIMIDINE NUCLEOSIDES OR NUCLEOTIDES
审中-公开
放射性联吡啶核苷或核苷酸的快速合成
- Patent Title: RAPID SYNTHESIS OF RADIOLABELED PYRIMIDINE NUCLEOSIDES OR NUCLEOTIDES
- Patent Title (中): 放射性联吡啶核苷或核苷酸的快速合成
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Application No.: PCT/US1996001264Application Date: 1996-02-01
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Publication No.: WO1996023806A1Publication Date: 1996-08-08
- Inventor: PRESIDENT AND FELLOWS OF HARVARD COLLEGE , KASSIS, Amin, I. , FOULON, Catherine, F. , ADELSTEIN, S., James
- Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
- Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
- Current Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
- Priority: US8/382,892 19950202
- Main IPC: C07H19/06
- IPC: C07H19/06
Abstract:
A method of making a radiolabeled pyrimidine nucleoside or nucleotide is described. In the method, an aqueous solution (i) a radioactive iodide, bromide, chlorine or astatide ion and (ii) a water soluble halomercuri pyrimidine nucleoside or nucleotide is contacted with an oxidizing agent, whereby a water soluble pyrimidine nucleoside or nucleotide labeled with radioactive iodine, bromine, chlorine or astatine is formed. Kits suitable for practicing the method are also disclosed.
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