Invention Application
WO1997035839A1 NOVEL BORNEOLS, PROCESSES FOR PRODUCING THEM AND PHARMACEUTICAL USE THEREOF
审中-公开
新冰片,PROCESS FOR THEIR和制药用
- Patent Title: NOVEL BORNEOLS, PROCESSES FOR PRODUCING THEM AND PHARMACEUTICAL USE THEREOF
- Patent Title (中): 新冰片,PROCESS FOR THEIR和制药用
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Application No.: PCT/EP1996001324Application Date: 1996-03-27
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Publication No.: WO1997035839A1Publication Date: 1997-10-02
- Inventor: SCHERING AKTIENGESELLSCHAFT
- Applicant: SCHERING AKTIENGESELLSCHAFT , KLAR, Ulrich , GRAF, Hermann , BLECHERT, Siegfried , SACHSE, Anke
- Assignee: SCHERING AKTIENGESELLSCHAFT,KLAR, Ulrich,GRAF, Hermann,BLECHERT, Siegfried,SACHSE, Anke
- Current Assignee: SCHERING AKTIENGESELLSCHAFT,KLAR, Ulrich,GRAF, Hermann,BLECHERT, Siegfried,SACHSE, Anke
- Main IPC: C07C271/02
- IPC: C07C271/02
Abstract:
The disclosure relates to borneol derivatives of general formula (I) wherein: R represents a phenyl residue optionally substituted by halogen atoms, C1-C4 alkyl groups, C1-C4 alkoxy groups, C1-C6 alkoxycarbonyl groups or C1-C8 acyloxy groups; R stands for a hydrogen atom, a C1-C4 alkyl group, substituted aryl, a C1-C6 alkoxycarbonyl group or a C1-C8 acyl group; R stands for a hydrogen atom, a C1-C4 alkyl group, a C1-C4 acyl group or a tri-C1-C4 alkylsilyl group; R and R represent a hydrogen atom, a C1-C4 alkyl residue or a phenyl residue optionally substituted by halogen atoms, C1-C4 alkyl group, C1-C9 alkoxy groups, C1-C4 alkoxycarbonyl groups or C1-C8 acyloxy groups; R and R stand for a hydrogen atom, hydroxy group or a C1-C8 acyloxy group, or together represent a carbon-carbon bond or oxygen atom; or R and R and/or R and R respectively stand together for a carbonyl group, a C1-C4 alkylidene group or if required an oxirane group substituted by a C1-C3 alkyl group. Also disclosed are the salts of these derivatives with physiologically tolerable acids, their alpha -, beta - or gamma -cyclodextrin clathrates and compounds of general formula (I) encapsulated in liposomes.
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