Invention Application
WO9850430A3 HEMOGLOBIN MUTANTS WITH INCREASED SOLUBLE EXPRESSION AND/OR REDUCED NITRIC OXIDE SCAVENGING
审中-公开
具有增加的可溶性表达和/或减少的氧化亚氮的HEMOGLOBIN MUTANT
- Patent Title: HEMOGLOBIN MUTANTS WITH INCREASED SOLUBLE EXPRESSION AND/OR REDUCED NITRIC OXIDE SCAVENGING
- Patent Title (中): 具有增加的可溶性表达和/或减少的氧化亚氮的HEMOGLOBIN MUTANT
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Application No.: PCT/US9808861Application Date: 1998-05-01
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Publication No.: WO9850430A3Publication Date: 1999-04-01
- Inventor: WEICKERT MICHAEL J , GLASCOCK CHRISTOPHER B , MATHEWS ANTONY J , LEMON DOUGLAS D , DOHERTY DANIEL H , OLSON JOHN S
- Applicant: SOMATOGEN INC , UNIV RICE WILLIAM M , WEICKERT MICHAEL J , GLASCOCK CHRISTOPHER B , MATHEWS ANTONY J , LEMON DOUGLAS D , DOHERTY DANIEL H , OLSON JOHN S
- Assignee: SOMATOGEN INC,UNIV RICE WILLIAM M,WEICKERT MICHAEL J,GLASCOCK CHRISTOPHER B,MATHEWS ANTONY J,LEMON DOUGLAS D,DOHERTY DANIEL H,OLSON JOHN S
- Current Assignee: SOMATOGEN INC,UNIV RICE WILLIAM M,WEICKERT MICHAEL J,GLASCOCK CHRISTOPHER B,MATHEWS ANTONY J,LEMON DOUGLAS D,DOHERTY DANIEL H,OLSON JOHN S
- Priority: US4536497 1997-05-02; US5798697 1997-09-05
- Main IPC: C12N15/09
- IPC: C12N15/09 ; A61K38/00 ; C07K14/805 ; C12N1/21 ; C12N5/06 ; C12N15/12 ; C12P21/02
Abstract:
The invention relates to novel recombinant hemoglobins having reduced nitric oxide scavenging and/or increased high soluble expression. The invention further relates to methods of increasing the soluble expression of recombinant hemoglobin by adding exogenous hemin in molar excess of the heme binding sites of recombinant hemoglobin.
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