Systems and methods support frequent hemofiltration at a designated treatment location (14) to provide a durable hemofiltration machine (16) at the site, and provide a disposable extracorporeal fluid circuit (18) for installation on the machine. The systems and methods provide a replacement fluid for connection to the extracorporeal fluid circuit. The systems and methods instruct use of the hemofiltration machine, extracorporeal fluid circuit, and replacement fluid at the site. Hemofiltration is carried out by (i) operating the hemofiltration machine to convey an individual's blood through the extracorporeal fluid circuit to a hemofilter at a blood flow rate of at least 300 ml/min to remove waste fluid, (ii) operating the hemofiltration machine to return treated blood, after removal of waste fluid, to the individual, and (iii) operating the hemofiltration machine to supply replacement fluid through the circuit to the individual, and (iv) performing (i), (ii), and (iii) at least four times weekly.