Invention Application
WO0242272A2 SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL PYRIDINES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE
审中-公开
用于选择性抑制凝聚剂CASCADE的取代的多环芳烃和异丁基吡啶
- Patent Title: SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL PYRIDINES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE
- Patent Title (中): 用于选择性抑制凝聚剂CASCADE的取代的多环芳烃和异丁基吡啶
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Application No.: PCT/US0143280Application Date: 2001-11-20
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Publication No.: WO0242272A2Publication Date: 2002-05-30
- Inventor: SOUTH MICHAEL S , CASE BRENDA , GARLAND DANNY J , HAYES MICHAEL J , HUANG HORNG-CHIH , HUANG WEI , JONES DARIN E , NEUMANN WILLIAM L , PARLOW JOHN J , REITZ DAVID B , RUEPPEL MELVIN L , WEBBER RONALD K
- Applicant: PHARMACIA CORP , SOUTH MICHAEL S , CASE BRENDA , GARLAND DANNY J , HAYES MICHAEL J , HUANG HORNG CHIH , HUANG WEI , JONES DARIN E , NEUMANN WILLIAM L , PARLOW JOHN J , REITZ DAVID B , RUEPPEL MELVIN L , WEBBER RONALD K
- Assignee: PHARMACIA CORP,SOUTH MICHAEL S,CASE BRENDA,GARLAND DANNY J,HAYES MICHAEL J,HUANG HORNG CHIH,HUANG WEI,JONES DARIN E,NEUMANN WILLIAM L,PARLOW JOHN J,REITZ DAVID B,RUEPPEL MELVIN L,WEBBER RONALD K
- Current Assignee: PHARMACIA CORP,SOUTH MICHAEL S,CASE BRENDA,GARLAND DANNY J,HAYES MICHAEL J,HUANG HORNG CHIH,HUANG WEI,JONES DARIN E,NEUMANN WILLIAM L,PARLOW JOHN J,REITZ DAVID B,RUEPPEL MELVIN L,WEBBER RONALD K
- Priority: US25215800 2000-11-20; US35006901 2001-11-07
- Main IPC: A61K31/44
- IPC: A61K31/44 ; A61K31/4418 ; A61K31/4436 ; A61K31/4439 ; A61K45/00 ; A61P7/02 ; A61P9/10 ; A61P11/00 ; A61P35/00 ; A61P43/00 ; C07D213/74 ; C07D213/89 ; C07D401/10 ; C07D409/04 ; C07D213/00
Abstract:
The present invention relates to compounds, and prodrugs thereof, composition and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.
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