发明申请
- 专利标题： EPHRIN AND EPH RECEPTOR MEDIATED IMMUNE MODULATION
- 专利标题（中）： EPHRIN和EPH受体介导的免疫调节
-
申请号： PCT/CA2002/001012申请日： 2002-07-03
-
公开(公告)号： WO2003004057A1公开(公告)日： 2003-01-16
- 发明人: ROIFMAN, Chaim, M. , FREYWALD, Andrew , SHARFE, Nigel , GRUNBERGER, Thomas , GRUNEBAUM, Eyal
- 申请人： THE HOSPITAL FOR SICK CHILDREN , ROIFMAN, Chaim, M. , FREYWALD, Andrew , SHARFE, Nigel , GRUNBERGER, Thomas , GRUNEBAUM, Eyal
- 申请人地址： 555 University Avenue, Toronto, Ontario M5G 1X8 CA
- 专利权人： THE HOSPITAL FOR SICK CHILDREN,ROIFMAN, Chaim, M.,FREYWALD, Andrew,SHARFE, Nigel,GRUNBERGER, Thomas,GRUNEBAUM, Eyal
- 当前专利权人： THE HOSPITAL FOR SICK CHILDREN,ROIFMAN, Chaim, M.,FREYWALD, Andrew,SHARFE, Nigel,GRUNBERGER, Thomas,GRUNEBAUM, Eyal
- 当前专利权人地址： 555 University Avenue, Toronto, Ontario M5G 1X8 CA
- 代理机构： KANG, Yoon
- 优先权： US60/302,385 20010703
- 主分类号： A61K45/00
- IPC分类号： A61K45/00
摘要：
Methods and compositions for immune modulation are described. The methods involve modulating an ephrin or Eph receptor which consequently modulates an immune response, in particular a T cell response, modulates immune adhesion cell, modulates chemotaxis and/or migration or modulates apoptosis. The method is useful in treating a variety of conditions including autoimmune disease, allergy, graft versus host disease, transplant rejection and cancer.
