发明申请
- 专利标题: HYDROXYFATTYSULFONIC ACID ANALOGS
- 专利标题(中): 羟基磺酸类似物
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申请号: PCT/US2002/025970申请日: 2002-09-09
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公开(公告)号: WO2003024922A1公开(公告)日: 2003-03-27
- 发明人: FALCK, John, R. , MIYATA, Noriyuki , ONO, Naoya , CHONAN, Tomomichi , HIRANO, Hitomi , TODA, Yoshihisa , TANAMI, Tohru , OKUYAMA, Shigeru
- 申请人: TAISHO PHARMACEUTICAL CO., LTD. , BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , FALCK, John, R. , MIYATA, Noriyuki , ONO, Naoya , CHONAN, Tomomichi , HIRANO, Hitomi , TODA, Yoshihisa , TANAMI, Tohru , OKUYAMA, Shigeru
- 申请人地址: 24-1, Takata 3-chome, Toshima-ku, Tokyo 170-8633 JP
- 专利权人: TAISHO PHARMACEUTICAL CO., LTD.,BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM,FALCK, John, R.,MIYATA, Noriyuki,ONO, Naoya,CHONAN, Tomomichi,HIRANO, Hitomi,TODA, Yoshihisa,TANAMI, Tohru,OKUYAMA, Shigeru
- 当前专利权人: TAISHO PHARMACEUTICAL CO., LTD.,BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM,FALCK, John, R.,MIYATA, Noriyuki,ONO, Naoya,CHONAN, Tomomichi,HIRANO, Hitomi,TODA, Yoshihisa,TANAMI, Tohru,OKUYAMA, Shigeru
- 当前专利权人地址: 24-1, Takata 3-chome, Toshima-ku, Tokyo 170-8633 JP
- 代理机构: MACK, Susan, J.
- 优先权: US60/318,874 20010914
- 主分类号: C07C309/01
- IPC分类号: C07C309/01
摘要:
A hydroxyfattysulfonic acid analog represented by Formula (I): wherein X is an ethylene group, a vinylene group or an ethynylene group; Y is an ethylene group, a vinylene group, an ethynylene group, OCH 2 or S(O)pCH 2 wherein p is 0, 1 or 2; m is an integer of 1 to 5 inclusive; n is an integer of 0 to 4 inclusive;R 1 is a C 1-8 alkyl group, a C 3-8 cycloalkyl group, a C 1-4 alkyl group substituted with a C 3-8 cycloalkyl group, a C 1-4 alkyl group substituted with an aryl group or a C 1-4 alkyl group substituted with an aryloxy group; R 2 is a hydrogen atom or a methyl group; R 1 and R 2 together with the carbon atom to which they are attached may form a C 3-8 cycloalkyl group; R 3 is a hydrogen atom or a C 2-8 acyl group; R 4 is OR 5 or NHR 6 , wherein R 5 is a hydrogen atom, a C 1-4 alkyl group, an alkali metal, an alkaline earth metal or an ammonium group and R 6 is a hydrogen atom or a C 1-4 alkyl group; or a pharmaceutically acceptable salt or a hydrate thereof. The compounds of the present invention are useful as an elastase release inhibitor.