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发明申请
WO2003030932A1 ATTENUATED MUTANT NEWCASTLE DISEASE VIRUS STRAINS FOR IN OVO VACCINATION, METHOD FOR PREPARING AND THEIR USE 审中-公开
用于OVO疫苗接种的减毒突变新城疫病毒株，制备方法及其用途

ATTENUATED MUTANT NEWCASTLE DISEASE VIRUS STRAINS FOR IN OVO VACCINATION, METHOD FOR PREPARING AND THEIR USE
摘要：
The present invention relates to new attenuated mutant New Castle's disease La SotaNewcastle disease virus strains. In particular, it relates to an attenuated mutant Newcastle's disease La SotaNewcastle disease virus strain suitable for in ovo vaccination of avian species comprising a mutation in the gene sequences encoding the HN and/or F glycoproteins of said virus resulting in an altered expression of said glycoproteins. Furthermore, the invention relates to a vaccine composition comprising said attenuated mutant Newcastle's disease La Sota virus strain, and to the use of said attenuated mutant Newcastle's disease La Sota virus strain for the preparation of a vaccine for in ovo vaccination of avian species against Newcastle's disease. Finally, the present invention also concerns a method for producing a vaccine for in ovo vaccination of avian species, said vaccine comprising attenuated mutant avian virus strains, which are selected using virus specific antibodies.
摘要（中）：

本发明涉及新的减毒突变New Castle's病La SotaNewcastle病毒株。 具体涉及适用于卵内疫苗接种禽类的减毒突变的新城疫La SotaNewcastle病病毒株，其包含编码所述病毒的HN和/或F糖蛋白的基因序列中的突变，导致所述糖蛋白的改变的表达 。 此外，本发明涉及包含所述减毒突变新城病La Sota病毒株的疫苗组合物，以及所述减毒突变新城疫La Sota病毒株用于制备用于卵内疫苗接种禽类抵抗新城疫的疫苗的用途 。 最后，本发明还涉及生产用于卵内疫苗接种禽类的疫苗的方法，所述疫苗包含使用病毒特异性抗体选择的减毒突变禽类病毒株。

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