Invention Application
- Patent Title: ALPHA-FETOPROTEIN PEPTIDES AND USES FOR IMAGING
- Patent Title (中): ALPHA-FETOPROTEIN胶囊和成像用途
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Application No.: PCT/US0237291Application Date: 2002-11-20
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Publication No.: WO03044041A2Publication Date: 2003-05-30
- Inventor: ANDERSEN THOMAS T , BENNETT JAMES A , JACOBSON HERBERT I , MESFIN FASSIL B
- Applicant: CLF MEDICAL TECHNOLOGY ACCELERATION PROGRAM INC , ANDERSEN THOMAS T , BENNETT JAMES A , JACOBSON HERBERT I , MESFIN FASSIL B
- Assignee: CLF MEDICAL TECHNOLOGY ACCELERATION PROGRAM INC,ANDERSEN THOMAS T,BENNETT JAMES A,JACOBSON HERBERT I,MESFIN FASSIL B
- Current Assignee: CLF MEDICAL TECHNOLOGY ACCELERATION PROGRAM INC,ANDERSEN THOMAS T,BENNETT JAMES A,JACOBSON HERBERT I,MESFIN FASSIL B
- Priority: US30053102 2002-11-20; US33184101 2001-11-20; US40910902 2002-09-09; US39701202 2002-07-19; US39737302 2002-07-19; US34092601 2001-12-07
- Main IPC: A61K38/00
- IPC: A61K38/00 ; C07K14/47 ; G01N33/574 ; C07K
Abstract:
The invention provides diagnostic procedures wherein the presence or absence of a cell-proliferating disorder, e.g., a breast cancer, may be determined. The imaging agents of the invention include alpha-fetoprotein hydrophilic analogs which have been determined to target cancers, e.g., breast cancer, and are also anti-cell proliferating in nature. These modulators contain amino acid structures which are arranged as a hydrophilic analog of an alpha-fetoprotein. The modulator may be a peptide; a peptidomimetic; or may be in the form of a pharmaceutically acceptable scaffold, such as a polycyclic hydrocarbon to which is attached the necessary amino acid structures. The imaging agents of the invention further comprise an imaging moiety that allows for the imaging of the area targeted by the imaging agent.
Information query
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