Invention Application
WO03044041A2 ALPHA-FETOPROTEIN PEPTIDES AND USES FOR IMAGING 审中-公开
ALPHA-FETOPROTEIN胶囊和成像用途

ALPHA-FETOPROTEIN PEPTIDES AND USES FOR IMAGING
Abstract:
The invention provides diagnostic procedures wherein the presence or absence of a cell-proliferating disorder, e.g., a breast cancer, may be determined. The imaging agents of the invention include alpha-fetoprotein hydrophilic analogs which have been determined to target cancers, e.g., breast cancer, and are also anti-cell proliferating in nature. These modulators contain amino acid structures which are arranged as a hydrophilic analog of an alpha-fetoprotein. The modulator may be a peptide; a peptidomimetic; or may be in the form of a pharmaceutically acceptable scaffold, such as a polycyclic hydrocarbon to which is attached the necessary amino acid structures. The imaging agents of the invention further comprise an imaging moiety that allows for the imaging of the area targeted by the imaging agent.
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