发明申请
- 专利标题： PYRROLOTRIAZINE KINASE INHIBITORS
- 专利标题（中）： 吡咯啉激酶抑制剂
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申请号： PCT/US2003/024273申请日： 2003-08-04
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公开(公告)号： WO2004013145A1公开(公告)日： 2004-02-12
- 发明人: BHIDE, Rajeev, S. , BORZILLERI, Robert, M.
- 申请人： BRISTOL-MYERS SQUIBB COMPANY , BHIDE, Rajeev, S. , BORZILLERI, Robert, M.
- 申请人地址： P. O. Box 4000, Route 206 and Provinceline Road, Princeton, NJ 08543-4000 US
- 专利权人： BRISTOL-MYERS SQUIBB COMPANY,BHIDE, Rajeev, S.,BORZILLERI, Robert, M.
- 当前专利权人： BRISTOL-MYERS SQUIBB COMPANY,BHIDE, Rajeev, S.,BORZILLERI, Robert, M.
- 当前专利权人地址： P. O. Box 4000, Route 206 and Provinceline Road, Princeton, NJ 08543-4000 US
- 代理机构： KORSEN, Elliott
- 优先权： US60/400,572 20020802
- 主分类号： C07D487/04
- IPC分类号： C07D487/04
摘要：
The present invention provides compounds of formula I, (I) and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
