A pneumatically assisted inflator for gas cylinders comprises an inline configuration such that gas contained within the gas cylinder flows axially through the inflator to be exhausted therefrom and inflate an inflatable article. The inline configuration of the inflator reduces the stress otherwise imparted to the component parts thereof and thereby allows most of the component parts to be manufactured from an injection molded high-strength plastic or the like. The inflator comprises an inflator piston positioned within a piston cylinder that moves against a rotatable cam surface, such as a rotatable collar connected to a pull lanyard, to force a pierce pin to make at least a small pin hole in a frangible seal and allow high pressure gas from the gas cylinder to flow into the piston cylinder, whereupon the high pressure gas in the piston cylinder further moves the inflator piston to more fully force the pierce pin into the frangible seal to fully open the frangible seal.