发明申请
WO2005044191A3 COMPOUNDS AND METHODS FOR TREATMENT OF CANCER AND MODULATION OF PROGRAMMED CELL DEATH FOR MELANOMA AND OTHER CANCER CELLS
审中-公开
治疗恶性黑色素瘤和其他癌症细胞的癌症和调节细胞死亡的化合物和方法
- 专利标题： COMPOUNDS AND METHODS FOR TREATMENT OF CANCER AND MODULATION OF PROGRAMMED CELL DEATH FOR MELANOMA AND OTHER CANCER CELLS
- 专利标题（中）： 治疗恶性黑色素瘤和其他癌症细胞的癌症和调节细胞死亡的化合物和方法
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申请号： PCT/US2004035746申请日： 2004-10-28
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公开(公告)号： WO2005044191A3公开(公告)日： 2005-10-20
- 发明人: HERGENROTHER PAUL J , NESTERENKO VITALIY , PUTT KARSON , ALLEN BRITTANY JOY , DOTHAGER ROBIN SHANE , LESLIE BENJAMIN JAMES
- 申请人： UNIV ALABAMA , HERGENROTHER PAUL J , NESTERENKO VITALIY , PUTT KARSON , ALLEN BRITTANY JOY , DOTHAGER ROBIN SHANE , LESLIE BENJAMIN JAMES
- 专利权人： UNIV ALABAMA,HERGENROTHER PAUL J,NESTERENKO VITALIY,PUTT KARSON,ALLEN BRITTANY JOY,DOTHAGER ROBIN SHANE,LESLIE BENJAMIN JAMES
- 当前专利权人： UNIV ALABAMA,HERGENROTHER PAUL J,NESTERENKO VITALIY,PUTT KARSON,ALLEN BRITTANY JOY,DOTHAGER ROBIN SHANE,LESLIE BENJAMIN JAMES
- 优先权： US51655603 2003-10-30; US60324604 2004-08-20; US97618604 2004-10-27
- 主分类号： A61K
- IPC分类号： A61K20060101 ; A61K31/165 ; A61K31/704 ; A61K31/7048 ; C07C233/05 ; C07C235/32
摘要：
Compounds and related methods for synthesis, and the use of compounds and combination therapies for the treatment of cancer and modulation of apoptosis in cells are disclosed. The generation of synthetic combinatorial libraries and the evaluation of library member compounds regarding induction of apoptosis selectively in cancer cells are disclosed. Compounds, methods of making the compounds, and therapeutic methods with application against breast cancer cells, melanoma cancer cells, colon cancer cells, and other cancer cells are described.
