发明申请
WO2005060665A8 3-CYCLOALKYLAMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS
审中-公开
作为化合物受体的调节剂的3-环丙基甲基吡咯烷酮衍生物
- 专利标题： 3-CYCLOALKYLAMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS
- 专利标题（中）： 作为化合物受体的调节剂的3-环丙基甲基吡咯烷酮衍生物
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申请号： PCT/US2004042321申请日： 2004-12-16
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公开(公告)号： WO2005060665A8公开(公告)日： 2006-05-04
- 发明人: XUE CHU-BIAO , METCALF BRIAN , HAN AMY QI , ROBINSON DARIUS J , ZHENG CHANGSHENG , WANG ANLAI , ZHANG YINGXIN
- 申请人： INCYTE CORP , XUE CHU-BIAO , METCALF BRIAN , HAN AMY QI , ROBINSON DARIUS J , ZHENG CHANGSHENG ZHENG CHANGSHENG , WANG ANLAI , ZHANG YINGXIN
- 专利权人： INCYTE CORP,XUE CHU-BIAO,METCALF BRIAN,HAN AMY QI,ROBINSON DARIUS J,ZHENG CHANGSHENG ZHENG CHANGSHENG,WANG ANLAI,ZHANG YINGXIN
- 当前专利权人： INCYTE CORP,XUE CHU-BIAO,METCALF BRIAN,HAN AMY QI,ROBINSON DARIUS J,ZHENG CHANGSHENG ZHENG CHANGSHENG,WANG ANLAI,ZHANG YINGXIN
- 优先权： US53127003 2003-12-18
- 主分类号： A61K31/4025
- IPC分类号： A61K31/4025 ; A61K31/427 ; A61K31/44 ; A61K31/4439 ; A61K31/506 ; C07D401/12 ; C07D401/14 ; C07D417/02
摘要：
The present invention relates to 3-cycloalkylaminopyrrolidine derivatives of the formula 1: (wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , X, Y and Z are as defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of chemokine receptors and more specifically as modulators of the CCR2 and/or CCR5 receptor. The compounds and compositions of the invention may bind to chemokine receptors, e.g., the CCR2 and/or CCR5 chemokine receptors, and are useful for treating diseases associated with chemokine, e.g., CCR2 and/or CCR5, activity, such as atherosclerosis, restenosis, lupus, organ transplant rejection and rheumatoid arthritis.
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